| Further Research Studies
The following studies are not funded by the Myositis
Support Group. Some of these investigations are recruiting whilst
others may be finished so please follow the related links for more
details.
Websites for searching clinical trials
1) http:///www.controlled-trials.com
2) http://www.clinicaltrials.gov
3) http://www.orpha.net
Clinical Trials
Multi-country Paediatric
Rheumatology International Trials Organisation (PRINTO) JDM trial.
Trial: Five-Year
Single-Blind, Phase III Effectiveness Randomised Actively Controlled
Clinical Trial in New Onset Juvenile Dermatomyositis: Prednisone
Versus Prednisone Plus Cyclosporine a Versus Prednisone Plus Methotrexate
Trial Duration: June
2006 - June 2013
Principal Investigator:
Dr Nicolino Ruperto (Italy)
A total of 185 centres from 46 different countries (110 centres
in 21 European States and 75 centres in 25 States outside the European
Union) are participating in the project.UK centres which are members
of the PRINTO network include; Birmingham (Institute of Child Health
Clinical Research Block), Bristol (Bristol Royal Hospital for Children),
Glasgow (Royal Alexandra Hospital), Leeds (Leeds General Infirmary
Department), Liverpool (Royal Liverpool Children's NHS Trust, Alder
Hey), London (University College London Centre for Paediatric and
Adolescent Rheumatology), Newcastle-Upon-Tyne (Newcastle University
School of Clinical Medical Sciences Musculoskeletal Research Group),
Nottingham (Queen's Medical Centre Department of Paediatric and
Adolescent Rheumatology), Oxford (Nuffield Orthopaedic Centre Department
of Paediatric Rheumatology), and Portsmouth (Queen Alexandra Hospital
Department of Rheumatology).
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info - Printo
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info - Orphanet
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info - Clinical Trials
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info - Controlled Trials
USA, University Pittsburgh
and additional centres throughout the world.
Trial: Rituximab
in the Treatment of Refractory Adult and Juvenile Dermatomyositis
and Adult Polymyositis.
Principal Investigator: Chester
Oddis.
Trial Duration: March
2006 – September 2008
A randomized, double-blind, placebo-phase, multi-centre, phase II
trial of intravenous rituximab in the treatment of refractory myositis
in adults and children, involving approximately 20 adult centres
and 17 paediatric clinical centres in the United States, Canada,
United Kingdom, Czech Republic and Sweden will be enrolling a total
of 200 participants.
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info - IMACS
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info - RIM
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info - Clinical Trials
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info - Controlled Trials
USA & Canada
Trial: A Pilot Study of
Etanercept in Adult Dermatomyositis
Principal Investigator:
Dr Amato
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info - IMACS
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info - Clinical Trials
France, Paris, Hôpital
Saint-Louis
Trial: FORCE:
phase II trial of rituximab in myositis linked to anti-JO1 or anti-SRP
antibodies or conventional treatment refractory myasthenia.
Principal Investigator: Dr
Olivier Benveniste
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info - Orphanet
Holland, Amsterdam,
Acedmic Medical Centre University of Amsterdam
Trial: Dexa-Myositis Trial.
Clinical trial investigating dexamethasone pulse therapy and prednisolone
treatments.
Principal Investigator: Dr
J. Van De Vlekkert
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info - Orphanet
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info - Clinical Trials
Austria
Trial: High dose intravenous
immunoglobulin in dermatomyositis
Principal Investigator: Dr
Beatrix Volc-Platzer
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info - Orphanet
Japan, Tokyo Medical
and Dental University
Trial: Efficacy and Safety
Study of GB-0998 for Treatment of Steroid-Resistant Polymyositis
and Dermatomyositis
Trial Start: June
2006
Principal Investigator: Hitoshi
Kohsaka
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info - Clinical Trials
France, Austria, Germany & Italy
Trial: Efficacy and safety
of L0133 in the Treatment of Dermatomyositis and Polymyositis: Prospective,
randomised, double-blind, placebo-controlled study
Trial Duration: September
2006 – March 2008
Principal Investigator: Dr
Patrick Dupuy
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info - Controlled Trials
USA, Washington
Trial: Pilot Study of Total
Body Irradiation in Combination With Cyclophosphamide, Anti-Thymocyte
Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell
Transplantation in Children With Refractory Autoimmune Disorders
Trial Start: November
2000
Principal Investigator:
Ann Woolfrey
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info - Clinical Trials
Sweden Stockholm Karolinska
University Hospital
Trial: Treatment with Interleukin-1
Receptor Antagonist (IL-1ra) in Patients with Chronic Inflammatory
Myopathies
Principal Investigator:
Dr Ingrid Lundberg
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info - IMACS
Sweden Stockholm Karolinska
University Hospital
Trial: Methotrexate in
Polymyositis and Dermatomyositis
Principal Investigator:
Dr Ingrid Lundberg
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info - IMACS
United Kingdom, London
and additional centres throughout the country
Trial: SELAM
Principal Investigator:
Dr Ernest Choy
Trial Duration: Patient
recruitment finished December 2006.
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info - IMACS
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info - ARC
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info - Clinical Trials
USA
Trial: Infliximab
in Polymyositis and Dermatomyositis
Principal Investigator:
Dr Paul Plotz
Trial Duration: 2003
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info - IMACS
USA, NIAMS Maryland
Trial: Safety
and Effectiveness of h5G1.1-mAb for Dermatomyositis
Trial Duration: April
2000-December 2001
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info - Controlled Trials
USA, NIHCC Maryland
Trial: Infliximab (Remicade)
to Treat Dermatomyositis and Polymyositis
Trial Start: April
2002
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info - Controlled Trials
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info - Clinical Trials
USA, NINDS Maryland
Trial: Intravenous Immunoglobulin
for the Treatment of Inflammatory Myopathies
Trial Duration: May 1990
– July 2002
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info - Controlled Trials
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info - Clinical Trials
Non-Treatment Research
United Kingdom, University
College London Centre for Paediatric and Adolescent Rheumatology
Study: JDM National Registry
& Repository of UK and Ireland
Study Duration: Established
in 2000 and Ongoing
Principal Investigator:
Professor Pat Woo
For more details>> (to be found)
USA
Study: Validation of IMACS
and PRINTO Definitions of Improvement
Principal Investigator:
Lisa Rider, Frederick Miller, Mark Gourley
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info - IMACS
IMACS (International
Myositis Assessment Consensus Study Group)
Study: The International Myositis Classification Criteria Project
Study Duration: ongoing
Principal Investigator: Dr
Ingrid Lundberg
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info - IMACS
Mexico
Study: Multi-centre Validation
Study of Revised Preliminary Definitions of Improvement
Principal Investigator:
I Garcia DeLaTorre
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info - IMACS
Hungary
Study: Short-, medium-
and long-term outcome in patients with Idiopathic Inflammatory Myopathy
Principal Investigator: Dr
Katalin Danko
Study Duration: 2003-2008
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info - IMACS
Germany
Study: Validation of IMACS
tools in Inclusion Body Myositis
Principal Investigator: Dr
Dieter Pongratz
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info - IMACS
Italy
Study: Multi-center
Long-term Outcome of Juvenile Dermatomyositis
Principal Investigator:
Dr. Angelo Ravelli
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info - IMACS
France, University Hospital of Rouen
Study:
myoARRAY and TcLandscape Analysis for the Diagnosis of Inflammatory
Myopathies
Study Duration:
2004 - 2006
Principal Investigator:
Dr Olivier Boyer
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info - Clinical Trials
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